Assigned to the 6th Air Force arriving at Albrook Field on March 23, 1943.
Extensively modified at the Panama Air Depot (PAD) at Albrook Field, including the removal of all armament, installation of a cargo bays for 2,500lbs of cargo, seats for 37 passengers and engine replacement with Pratt & Whitney R-1830 engines.
Redesignated XC-105 on May 6, 1943. During July-August referred to as "EC-105". This aircraft made many long distance flights, including a non-stop flight to the United States, plus missions to Galapagos.
During August 1943, assigned to the 20th Troop Carrier Squadron. Sometime in late 1943 or early 1944, this aircraft was stripped to bare aluminium finish. Parked at Seymour Island Airfield in the Galapagos on April 30, 1945.
In service for eight years, the XB-15 carried more than 5,200 passengers, 440,000 pounds of cargo and 94,000 pounds of mail. It flew 70 cargo trips and 60 missions including anti-submarine patrol.
During May 1944, placed into storage at PAD at Albrook Field, possibly due to structural damage. Stripped of parts and the tail, the rest of the aircraft was bulldozed into a swamp to the east of Albrook Field.
Frank Holmann adds: