Midget Sub Carrier
Participated in the Battle of Midway strike force's 'main body', carrying midget submarines, for the Japanese base expected to be establish there after it is occupied. When the Japanese are defeated, Nisshin returns to Hashirajima on June 19th.
Guadalcanal "Tokyo Express" Runs
First Mission: On October 3, 1942 Nisshin is loaded with nine artillery pieces (including 150mm howitzers) and 330 men including General Maruyama Masao of the 2nd Division. Departs Shortland at 6:30am with Chitose escorted by destroyers Nowaki, Maikaze and Akitsuki. At 3:40 Nisshin was attacked by five B-17s, but not damaged. Afterwards arrives at Tassafaronga unloading began. At 10:00pm Nisshin is attacked at night and suffers a near miss by an aerial bomb, causing an engine room leak. She departs before fully unloading, leaving with 80 men still aboard and two artillery. The ship departs without further damage and Akizuki joins her escort.
Second Mission: On October 7th, departs Shortland on a second "Tokyo Express' run, but the mission is aborted halfway, as no air cover is available. On October 8, 1942 again departs Shortland with six anti-aircraft guns, two howitzers and 180 soldiers, escorted by Akizuki and four other destroyers loaded with other troops. After successfully unloading on Guadalcanal, the group is attacked on the return trip but suffers no damage.
#3: On October 11th, Nisshin and Chitose depart Shortland with more howitzers, guns, equipment and troops, escorted by six destroyers, while Cruiser Division 6 accompanies as a bombardment group. At 10:20pm arrives at for Tassafaronga and successfully unload as the Battle of Cape Esperence commences. Nisshin and Chitose withdraw.
#4 Departs Shortland and on October 14, unloads soldiers at Cape Esperence, and returns to Shortland on November 1st, then departs for Truk arriving on the 3rd, then departs on the 23rd, arriving at Yokosuka. Captain Ito Jotaro becomes new commander.
Arrives at Truk on July 14, then departs on the 19th for Rabaul with along with escorts: Hatsuzuki, Mogami, Oyodo and Agano. Arrives at Rabaul on the 21st, loads additional troops and departs for the Shortland that evening. At 11pm, enemy planes are sited but reinforcement continues. Allied ULTRA had deciphers the details of the convoy and an air attack is planned against the convoy
Next, attacked by SBD Dauntless at 1:53 at close range, and suffers three hits: one on the No. 2 turret, one on front aircraft deck and third inside the aircraft hanger, open for unloading. Electrical power is cut and the ship's speed drops and jams the rudder, but is reset to center.
At 1:59 a third strike scores two additional hits on the port side, causing the ship to list sharply and sink by the bow. A sixth bomb hits on the starboard side, yet anti-aircraft gunners continue to fire as the ship ship sinks. Although an abandon ship is ordered, there is not enough time of troops or crew to escape.
At 2:05, the Nisshin rolled to starboard and sinks bow first. Escorting destroyers search for survivors for two hours. Less than 200 survived the swift sinking.
Officially, the Nisshin is stricken from the register on September 10, 1943.